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KMID : 0363320110320030345
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Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 3 p.345 ~ p.360
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The Effect of Cheonmagudeng-um gagam(CGG) on Spontaneous Hypertensive Rat(SHR)
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Song Byoung-Yong
Choi Eun-Hee
Jung Tae-San
Kang Seong-Sun
An Ga-Yong
Kim Oh-Young
Jeon Sang-Yun
Hong Seok
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Abstract
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Objectives: This study was examined to investigate the effects of Cheonmagudeng-um gagam (CGG) extract on spontaneous hypertension.
Methods: For the study of CGG, we divided rats into three groups. The normal group was Wister Kyoto rats (WKY). The control group was spontaneously hypertensive rats (SHR). The treatment group was SHR which were administered CGG extract (SHR-CGG). SHR-CGG were orally administered CGG extract that was diluted in distilled water at the various concentrations for 4 weeks (234.5 mg/kg) and SHR were orally administered the same dosage of plain distilled water as SHR-CGG. Then we measured anti-oxygen effects, ACE inhibitory activity, weight of heart and kidney, blood pressure, heart rate, plasma aldosterone, electrolyte, creatinine, uric acid, BUN, and observed the cortex of the cardiac muscle, kidney, and adrenal gland.
Results: CGG increased DPPH scavenging activity and SOD similar activity depending on the concentration. CGG significantly decreased ROS, TNF-, IL-6, IL-, heart weight, blood pressure, heart rate, aldosterone, and BUN in SHR. CGG increased ACE inhibition activity depending on the concentration. CGG inhibited the heart, kidney and adrenal gland tissue injury that is caused by hypertension.
Conclusions: These results suggest that CGG is effective in treatment and prevention of hypertension.
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KEYWORD
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spontaneously hypertensive rat, Cheonmagudeng-um gagam (tinmgutng-yn jijin)
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